Molecular Endocrinology

Department of Internal Medicine I

Group Members

Jens Mittag (Group leader)
Rebecca Ölkrug (Postdoc)
Sogol Gachkar (PhD student)
Lisbeth Harder (PhD student)
Beate Herrmann (PhD student)
Kornelia Johann (PhD student)
Sebastian Nock (PhD student shared with Prof. Georg Brabant)
Francesca Raffaelli (PhD student shared with Dr. Alexander Iwen)
Maike Byner (MD student)

Alexander Iwen (MD, leader clinical studies)


Research Interests

Our research centers around the role of thyroid hormone in the coordination of cardiovascular parameters and thermoregulatory processes. On one hand we are interested in dissecting the role of thyroid hormone on the central control of heart rate, blood pressure and brown fat thermogenesis, with a special focus on a novel population of parvalbuminergic neurons in the anterior hypothalamus. On the other hand we investigate the direct effects of thyroid hormone and its metabolites on brown fat, heart and vasculature using for instance infrared thermography, radiotelemetry and wire myography.


Collaborations

  • Heike Heuer, Leibniz Institute for Environmental Medicine Düsseldorf)
  • Lutz Schomburg, Heike Biebermann, Carolin Höfig (Charité Berlin)
  • Björn Vennström, Prof. Anders Arner (Karolinska Institutet Stockholm)


Latest Publications

Jens Mittag

  1. Warner A, Mittag J: “Breaking BAT – Can Browning Create a Better White?” J Endocrinol. 2016 Jan;228(1):R19-29.
  2. Hoefig CS, Harder L, Oelkrug R, Meusel M, Vennström B, Brabant G, Mittag J: “Thermoregulatory and Cardiovascular Consequences of a Transient Thyrotoxicosis and Recovery in Male Mice” Endocrinology 2016 Jul;157(7):2957-67
  3. Höfig CS, Jacobi SF, Warner A, Harder L, Schanze N, Vennström B, Mittag J: “3-Iodoacetic acid lacks thermoregulatory and cardiovascular effects in vivo” British Journal of Pharmacology 2015 Jul;172(13):3426-33
  4. Warner A, Rahman A, Solsjö P, Gottschling K, Davis B, Vennström B, Arner A, Mittag J: “Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor α1", Proceedings of the National Academy of Sciences USA 2013, Oct 1;110(40):16241-16246
  5. Mittag J, Lyons D, Sällström J, Vujovic M, Dudazy-Gralla S, Warner A, Wallis K, Alkemade A, Nordström K, Monyer H, Broberger C, Arner A, Vennström B: “Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions” Journal of Clinical Investigation 2013 Jan 2;123(1):509

Alexander Iwen

  1. Kohlie R, Perwitz N, Resch J, Schmid SM, Lehnert H, Klein J, Iwen KA: "Dopamine directly increases mitochondrial mass and thermogenesis in brown adipocytes." 2017 J Mol Endocrinol 58:57-66
  2. Iwen KA, Scherer T, Heni M, Sayk F, Wellnitz T, Machleidt F, Preissl H, Haring HU, Fritsche A, Lehnert H, Buettner C, Hallschmid M: "Intranasal insulin suppresses systemic but not subcutaneous lipolysis in healthy humans." 2014 J Clin Endocrinol Metab 99:E246-251
  3. Iwen KA, Schroder E, Brabant G: "Thyroid hormones and the metabolic syndrome." 2013 Eur Thyroid J 2:83-92