Transdiagnostic Neuroscience

Translational Psychiatry Unit

Group Members

Rebekka Lencer, MD (Group Leader)
Claudia Lange, PhD
Jan-Ole Radecke (Post-doc)
Inga Meyhöfer, PhD (Post-doc)
Benjamin Tari (Guest Researcher)
Henrieke Hell (MD)
Hannah Stöckler (MD candidate)

Research Interests

We aim at a better understanding of neural and functional disease mechanisms involved in major psychiatric disorders by studying familial neurobiological markers such as alterations in eye movement control. Following a translational approach using knowledge from non-human primate studies, we are using novel methodological approaches from neurophysiology, brain imaging (fMRI, EEG, MEG), brain stimulation (tDCS, TMS), and molecular genetics both in healthy individuals and clinical patient populations. Alterations in biological markers are used to guide novel treatment approaches to be applied to specific clusters of biomarkers. In our more clinically focussed work, we are interested in processes enhancing treatment adherence based on cognitive behavioral therapy. 

Our most recent project funded by DFG: Multi-channel transcranial direct current stimulation (mc-tDCS): a novel approach to modulate smooth pursuit eye movement control in healthy individuals and patients with psychotic disorders (2021-2024).

Collaborations (selection of most recent)

  • Markus Lappe, University Münster
  • Carsten Wolters, University Münster
  • Nikos Koutsouleris, LMU Munich
  • John A. Sweeney, University of Cincinnati, USA
  • Su Lui, University of Chengdu, China

Publications

  1. Koutsouleris N, Dwyer DB, Degenhardt F, Maj C, Urquijo-Castro MF, Sanfelici R, Popovic D, Oeztuerk O, Haas SS, Weiske J, Ruef A, Kambeitz-Ilankovic L, Antonucci LA, Neufang S, Schmidt-Kraepelin C, Ruhrmann S, Penzel N, Kambeitz J, Haidl TK, Rosen M, Chisholm K, Riecher-Rössler A, Egloff L, Schmidt A, Andreou C, Hietala J, Schirmer T, Romer G, Walger P, Franscini M, Traber-Walker N, Schimmelmann BG, Flückiger R, Michel C, Rössler W, Borisov O, Krawitz PM, Heekeren K, Buechler R, Pantelis C, Falkai P, Salokangas RKR, Lencer R, Bertolino A, Borgwardt S, Noethen M, Brambilla P, Wood SJ, Upthegrove R, Schultze-Lutter F, Theodoridou A, Meisenzahl E; Writing Group for the PRONIA Consortium (2021) Multimodal Machine Learning Workflows for Prediction of Psychosis in Patients With Clinical High-Risk Syndromes and Recent-Onset Depression. JAMA Psychiatry 2021 Feb 1:78 (2):195-209. https://doi.org/10.1001/jamapsychiatry.2020.3604 
  2. Agtzidis, I., Meyhöfer, I., Dorr, M., Lencer, R. (2020). Following Forrest Gump: smooth pursuit related brain activation during free movie viewing. Neuroimage. 2020 Jan 7:116491. https://doi.org/10.1016/j.neuroimage.2019.116491
  3. Lencer R, Yao L, Reilly JL, Keedy SK, McDowell JE, Keshavan MS, Pearlson GD, Tamminga CA, Gershon ES; Clementz BA, Lui S, Sweeney JA (2019) Alterations in intrinsic fronto-thalamo-parietal connectivity are associated with cognitive control deficits in psychotic disorders. Human Brain Mapping 40(1):163-174. https://doi.org/10.1002/hbm.24362
  4. Lencer R, Mills LJ, Alliey-Rodriguez N; Shafee R, Lee A, Reilly JL, Sprenger A, McDowell JE, McCarroll SA, Keshavan MS, Pearlson GD, Tamminga CA,Clementz BA, Gershon ES, Sweeney JA, Bishop JR (2017). Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study. Translational Psychiatry 7, e1249; https://doi.org/10.1038/tp.2017.210
  5. Trillenberg P, Sprenger A, Talamo S, Herold K, Helmchen C, Verleger R, Lencer R (2017) Visual and non-visual motion information processing during pursuit eye tracking in schizophrenia and bipolar disorder. European Archives of Psychiatry and Clinical Neuroscience 267(3):225-235. https://doi.org/10.1007/s00406-016-0671-z

see also pubmed link for R Lencer