Selected Publications 2016-2020


Acaz-Fonseca E, Ortiz-Rodriguez A, Garcia-Segura LM, Astiz M (2020) Sex differences and gonadal hormone regulation of brain cardiolipin, a key mitochondrial phospholipid. J Neuroendocrinol 32:e12774.

Adamczyk WM, Szikszay TM, Kung T, Carvalho GF, Luedtke K (2020) Not as 'blurred' as expected? Acuity and spatial summation in the pain system. Pain in press

Aherrahrou R, Kulle AE, Alenina N, Werner R, Vens-Cappell S, Bader M, Schunkert H, Erdmann J, Aherrahrou Z (2020) CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development. Sci Rep 10:8792.

Altenmuller DM, Hebel JM, Deniz C, Volz S, Zentner J, Feuerstein TJ, Moser A (2020) Electrocorticographic and neurochemical findings after local cortical valproate application in patients with pharmacoresistant focal epilepsy. Epilepsia 61:e60-e65.

Dore R, Krotenko R, Reising JP, Murru L, Sundaram SM, Di Spiezio A, Müller-Fielitz H, Schwaninger M, Jöhren O, Mittag J, Passafaro M, Shanabrough M, Horvath TL, Schulz C, Lehnert H (2020) Nesfatin-1 decreases the motivational and rewarding value of food. Neuropsychopharmacology 45:1645-1655.

Friedrich M, Mölle M, Friederici AD, Born J (2020) Sleep-dependent memory consolidation in infants protects new episodic memories from existing semantic memories. Nat Commun 11:1298.

Herrmann B, Harder L, Oelkrug R, Chen J, Gachkar S, Nock S, Resch J, Korkowski M, Heuer H, Mittag J (2020) Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone-Induced Cardiac Hypertrophy and Pyrexia. Thyroid 30:1205-1216.

Koch CE, Begemann K, Kiehn JT, Griewahn L, Mauer J, Hess ME, Moser A, Schmid SM, Brüning JC, Oster H (2020) Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA. Nat Commun 11:3071.

Mehl S, Sun Q, Görlich CL, Hackler J, Kopp JF, Renko K, Mittag J, Schwerdtle T, Schomburg L (2020) Cross-sectional analysis of trace element status in thyroid disease. J Trace Elem Med Biol 58:126430.

Mittag J (2020) More Than Fever - Novel Concepts in the Regulation of Body Temperature by Thyroid Hormones. Exp Clin Endocrinol Diabetes 128:428-431.

Rawish E, Nickel L, Schuster F, Stölting I, Frydrychowicz A, Saar K, Hübner N, Othman A, Kuerschner L, Raasch W (2020) Telmisartan prevents development of obesity and normalizes hypothalamic lipid droplets. J Endocrinol 244:95-110.

Wilms B, Kuhr M, Chamorro R, Klinsmann N, Spyra D, Mölle M, Kalscheuer H, Schultes B, Lehnert H, Schmid SM (2020) Chronobiological aspects of sleep restriction modulate subsequent spontaneous physical activity. Physiol Behav 215:112795.

Wilz AM, Wernecke K, Appel L, Kahrs J, Dore R, Jöhren O, Lehnert H, Schulz C (2020) Endogenous NUCB2/Nesfatin-1 Regulates Energy Homeostasis Under Physiological Conditions in Male Rats. Horm Metab Res.

Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O (2020) Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography. J Cereb Blood Flow Metab 40:954-965.



Alavash M, Tune S, Obleser J (2019) Modular reconfiguration of an auditory control brain network supports adaptive listening behavior. Proc Natl Acad Sci U S A 116:660-669.

Besedovsky L, Lange T, Haack M (2019) The Sleep-Immune Crosstalk in Health and Disease. Physiol Rev 99:1325-1380.

Dapper C, Schuster F, Stölting I, Vogt F, Castro ESLA, Alenina N, Bader M, Raasch W (2019) The antiobese effect of AT1 receptor blockade is augmented in mice lacking Mas. Naunyn Schmiedebergs Arch Pharmacol 392:865-877.

Dimitrov S, Lange T, Gouttefangeas C, Jensen ATR, Szczepanski M, Lehnnolz J, Soekadar S, Rammensee HG, Born J, Besedovsky L (2019) Galphas-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells. J Exp Med 216:517-526.

Friedrich M, Mölle M, Friederici AD, Born J (2019) The reciprocal relation between sleep and memory in infancy: Memory-dependent adjustment of sleep spindles and spindle-dependent improvement of memories. Dev Sci 22:e12743.

Kalscheuer H, Seufert J, Lanzinger S, Rosenbauer J, Karges W, Bergis D, Mader JK, Zimny S, Schmid SM, Hummel M, Kerner W, Holl RW, Initiative DPV (2019) Event Rates and Risk Factors for the Development of Diabetic Ketoacidosis in Adult Patients With Type 1 Diabetes: Analysis From the DPV Registry Based on 46,966 Patients. Diabetes Care 42:e34-e36.

Kim P, Oster H, Lehnert H, Schmid SM, Salamat N, Barclay JL, Maronde E, Inder W, Rawashdeh O (2019) Coupling the Circadian Clock to Homeostasis: The Role of Period in Timing Physiology. Endocr Rev 40:66-95.

Krusche J, Twardziok M, Rehbach K, Böck A, Tsang MS, Schröder PC, Kumbrink J, Kirchner T, Xing Y, Riedler J, Dalphin JC, Pekkanen J, Lauener R, Roponen M, Li J, Wong CK, Wong GWK, Schaub B (2019) TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection. J Allergy Clin Immunol 144:1684-1696.e1612.

Lang C, Campbell KR, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, Hu MT, Cowley SA, Webber C, Wade-Martins R (2019) Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes. Cell Stem Cell 24:93-106.e106.

Levata L, Dore R, Jöhren O, Schwaninger M, Schulz C, Lehnert H (2019) Nesfatin-1 Acts Centrally to Induce Sympathetic Activation of Brown Adipose Tissue and Non-Shivering Thermogenesis. Horm Metab Res 51:678-685.

Luedtke K, Schulte LH, May A (2019) Visual processing in migraineurs depends on the migraine cycle. Ann Neurol 85:280-283.

Olbrisch K, Kisch T, Thern J, Kramme E, Rupp J, Graf T, Wicha SG, Mailänder P, Raasch W (2019) After standard dosage of piperacillin plasma concentrations of drug are subtherapeutic in burn patients. Naunyn Schmiedebergs Arch Pharmacol 392:229-241.

Preckel K, Trautwein FM, Paulus FM, Kirsch P, Krach S, Singer T, Kanske P (2019) Neural mechanisms of affective matching across faces and scenes. Sci Rep 9:1492.

Rothe M, Rommel F, Klapa S, Humrich JY, Nieberding R, Lange T, Sochurek JAM, Plottner P, Grisanti S, Riemekasten G, Ranjbar M (2019) Evaluation of retinal microvascular perfusion in systemic sclerosis: a case-control study. Ann Rheum Dis.



Beste C, Moll CKE, Potter-Nerger M, Munchau A (2018) Striatal Microstructure and Its Relevance for Cognitive Control. Trends Cogn Sci 22:747-751.

Birnbaum W, Marshall L, Werner R, Kulle A, Holterhus PM, Rall K, Kohler B, Richter-Unruh A, Hartmann MF, Wudy SA, Auer MK, Lux A, Kropf S, Hiort O (2018) Oestrogen versus androgen in hormone-replacement therapy for complete androgen insensitivity syndrome: a multicentre, randomised, double-dummy, double-blind crossover trial. Lancet Diabetes Endocrinol 6:771-780.

Bräunig J, Mergler S, Jyrch S, Hoefig CS, Rosowski M, Mittag J, Biebermann H, Khajavi N (2018) 3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines. Front Endocrinol (Lausanne) 9:523.

Bräunig J, Dinter J, Höfig CS, Paisdzior S, Szczepek M, Scheerer P, Rosowski M, Mittag J, Kleinau G, Biebermann H (2018) The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor. Front Pharmacol 9:222.

Bruggemann N, Domingo A, Rasche D, Moll CKE, Rosales RL, Jamora RDG, Hanssen H, Munchau A, Graf J, Weissbach A, Tadic V, Diesta CC, Volkmann J, Kuhn A, Munte TF, Tronnier V, Klein C (2018) Association of Pallidal Neurostimulation and Outcome Predictors With X-linked Dystonia Parkinsonism. JAMA Neurol.

Cabral-Marques O et al. (2018) GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis. Nat Commun 9:5224.

Diekelmann S, Paulus FM, Krach S (2018) Sleep to be social: The critical role of sleep and memory for social interaction. Behav Brain Sci 41:e10.

Epp A et al. (2018) Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. J Allergy Clin Immunol 141:399-402.e398.

Gronier B, Savignac HM, Di Miceli M, Idriss SM, Tzortzis G, Anthony D, Burnet PWJ (2018) Increased cortical neuronal responses to NMDA and improved attentional set-shifting performance in rats following prebiotic (B-GOS(®)) ingestion. Eur Neuropsychopharmacol 28:211-224.

Harder L, Dudazy-Gralla S, Müller-Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J (2018) Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area. J Neuroendocrinol 30:e12573.

Harder L, Schanze N, Sarsenbayeva A, Kugel F, Köhrle J, Schomburg L, Mittag J, Hoefig CS (2018) In vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice. Eur Thyroid J 7:3-12.

Jastroch M, Oelkrug R, Keipert S (2018) Insights into brown adipose tissue evolution and function from non-model organisms. J Exp Biol 221.

Jöhren O (2018) Orexins/hypocretins and sex. Peptides 99:115-116.

Park SQ, Schmid SM (2018) Reply to Raison and Raichlen: Why does nutrition impact social decision making? Proc Natl Acad Sci U S A 115:E1332-E1333.

Park MH, Lee JY, Park KH, Jung IK, Kim KT, Lee YS, Ryu HH, Jeong Y, Kang M, Schwaninger M, Gulbins E, Reichel M, Kornhuber J, Yamaguchi T, Kim HJ, Kim SH, Schuchman EH, Jin HK, Bae JS (2018) Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM. Neuron 100:762.

Schmidt S et al. (2018) ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. J Exp Med 215:1205-1225.

Schuster F, Huber G, Stölting I, Wing EE, Saar K, Hübner N, Banks WA, Raasch W (2018) Telmisartan prevents diet-induced obesity and preserves leptin transport across the blood-brain barrier in high-fat diet-fed mice. Pflugers Arch 470:1673-1689.

Seibler P, Burbulla LF, Dulovic M, Zittel S, Heine J, Schmidt T, Rudolph F, Westenberger A, Rakovic A, Munchau A, Krainc D, Klein C (2018) Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells. Brain 141:3052-3064.

Seong E, Insolera R, Dulovic M, Kamsteeg EJ, Trinh J, Bruggemann N, Sandford E, Li S, Ozel AB, Li JZ, Jewett T, Kievit AJA, Munchau A, Shakkottai V, Klein C, Collins CA, Lohmann K, van de Warrenburg BP, Burmeister M (2018) Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects. Ann Neurol 83:1075-1088.

Winkler M, Bader M, Schuster F, Stölting I, Binder S, Raasch W (2018) Development of obesity can be prevented in rats by chronic icv infusions of AngII but less by Ang(1-7). Pflugers Arch 470:867-881.



Bäumer T, Grimm A, Schelle T (2017) [Diagnostic nerve ultrasonography]. Radiologe 57:157-165.

Bergroth E, Roponen M, Karvonen AM, Keski-Nisula L, Remes S, Riedler J, Roduit C, Dalphin JC, Kaulek V, Loss GJ, Lauener R, Hirvonen MR, Genuneit J, Schmaußer-Hechfellner E, Renz H, Pfefferle PI, Krauss-Etschmann S, Schaub B, von Mutius E, Pekkanen J (2017) Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy. Pediatr Allergy Immunol 28:53-59.

Cabral-Marques O, Riemekasten G (2017) Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases. Nat Rev Rheumatol 13:648-656.

Dogbevia GK, Tollner K, Korbelin J, Broer S, Ridder DA, Grasshoff H, Brandt C, Wenzel J, Straub BK, Trepel M, Loscher W, Schwaninger M (2017) Gene therapy decreases seizures in a model of Incontinentia pigmenti. Ann Neurol 82:93-104.

Dore R, Levata L, Lehnert H, Schulz C (2017) Nesfatin-1: functions and physiology of a novel regulatory peptide. J Endocrinol 232:R45-r65.

Dore R, Levata L, Gachkar S, Jöhren O, Mittag J, Lehnert H, Schulz C (2017) The thermogenic effect of nesfatin-1 requires recruitment of the melanocortin system. J Endocrinol 235:111-122.

Druzd D et al. (2017) Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Immunity 46:120-132.

Friedrich M, Wilhelm I, Mölle M, Born J, Friederici AD (2017) The Sleeping Infant Brain Anticipates Development. Curr Biol 27:2374-2380.e2373.

Henry MJ, Herrmann B, Kunke D, Obleser J (2017) Aging affects the balance of neural entrainment and top-down neural modulation in the listening brain. Nat Commun 8:15801.

Hose AJ, Depner M, Illi S, Lau S, Keil T, Wahn U, Fuchs O, Pfefferle PI, Schmaußer-Hechfellner E, Genuneit J, Lauener R, Karvonen AM, Roduit C, Dalphin JC, Riedler J, Pekkanen J, von Mutius E, Ege MJ (2017) Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts. J Allergy Clin Immunol 139:1935-1945.e1912.

Huber G, Schuster F, Raasch W (2017) Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases. Pharmacol Res 125:72-90.

Jendrek ST et al. (2017) Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. Gut 66:137-144.

Martinez-Sanchez N et al. (2017) Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab 26:212-229.e212.

Melzer C, Hass R, von der Ohe J, Lehnert H, Ungefroren H (2017) The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma. Cell Commun Signal 15:19.

Mildner M, Müller-Fielitz H, Stölting I, Jöhren O, Steckelings M, Raasch W (2017) Glucagon increase after chronic AT(1) blockade is more likely related to an indirect leptin-dependent than to a pancreatic α-cell-dependent mechanism. Naunyn Schmiedebergs Arch Pharmacol 390:505-518.

Muller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M (2017) Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun 8:484.

Oelkrug R, Herrmann B, Geissler C, Harder L, Koch C, Lehnert H, Oster H, Kirchner H, Mittag J (2017) Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy. Mol Metab 6:1126-1136.

Oster H, Challet E, Ott V, Arvat E, de Kloet ER, Dijk DJ, Lightman S, Vgontzas A, Van Cauter E (2017) The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids. Endocr Rev 38:3-45.

Peters A, McEwen BS, Friston K (2017) Uncertainty and stress: Why it causes diseases and how it is mastered by the brain. Prog Neurobiol 156:164-188.

Schanze N, Jacobi SF, Rijntjes E, Mergler S, Del Olmo M, Hoefig CS, Khajavi N, Lehmphul I, Biebermann H, Mittag J, Köhrle J (2017) 3-Iodothyronamine Decreases Expression of Genes Involved in Iodide Metabolism in Mouse Thyroids and Inhibits Iodide Uptake in PCCL3 Thyrocytes. Thyroid 27:11-22.

Schramm A, Huber D, Möbius C, Münchau A, Kohl Z, Bäumer T (2017) Involvement of obliquus capitis inferior muscle in dystonic head tremor. Parkinsonism Relat Disord 44:119-123.

Schröder PC, Illi S, Casaca VI, Lluis A, Böck A, Roduit C, Depner M, Frei R, Genuneit J, Pfefferle PI, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Dalphin JC, Pekkanen J, Lauener R, von Mutius E, Schaub B (2017) A switch in regulatory T cells through farm exposure during immune maturation in childhood. Allergy 72:604-615.

Strang S, Hoeber C, Uhl O, Koletzko B, Munte TF, Lehnert H, Dolan RJ, Schmid SM, Park SQ (2017) Impact of nutrition on social decision making. Proc Natl Acad Sci U S A 114:6510-6514.

Tang AT et al. (2017) Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature 545:305-310.

Tiedemann LJ, Schmid SM, Hettel J, Giesen K, Francke P, Buchel C, Brassen S (2017) Central insulin modulates food valuation via mesolimbic pathways. Nat Commun 8:16052.

Tunc S, Munchau A (2017) Boys in a famous choir: Singing and ticcing. Ann Neurol 82:1029-1031.

Weissbach A, Werner E, Bally JF, Tunc S, Lons S, Timmann D, Zeuner KE, Tadic V, Bruggemann N, Lang A, Klein C, Munchau A, Baumer T (2017) Alcohol improves cerebellar learning deficit in myoclonus-dystonia: A clinical and electrophysiological investigation. Ann Neurol 82:543-553.

Werth S, Müller-Fielitz H, Raasch W (2017) Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. J Endocrinol 235:251-265.



Blank T et al. (2016) Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment. Immunity 44:901-912.

Blasig S, Kühnen P, Schuette A, Blankenstein O, Mittag J, Schomburg L (2016) Positive correlation of thyroid hormones and serum copper in children with congenital hypothyroidism. J Trace Elem Med Biol 37:90-95.

Cools M, Simmonds M, Elford S, Gorter J, Ahmed SF, D'Alberton F, Springer A, Hiort O, Management Committee of the European Cooperation in S, Technology Action BM (2016) Response to the Council of Europe Human Rights Commissioner's Issue Paper on Human Rights and Intersex People. Eur Urol 70:407-409.

Fritz M et al. (2016) Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. J Clin Invest 126:695-705.

Hirose M, Schilf P, Gupta Y, Wright MN, Wright MN, Jöhren O, Wagner AE, Sina C, Ziegler A, Ristow M, Ibrahim SM (2016) Lifespan effects of mitochondrial mutations. Nature 540:E13-e14.

Hoefig CS, Harder L, Oelkrug R, Meusel M, Vennström B, Brabant G, Mittag J (2016) Thermoregulatory and Cardiovascular Consequences of a Transient Thyrotoxicosis and Recovery in Male Mice. Endocrinology 157:2957-2967.

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Forster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Bruning JC (2016) Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell 166:1338-1340.

Korbelin J, Dogbevia G, Michelfelder S, Ridder DA, Hunger A, Wenzel J, Seismann H, Lampe M, Bannach J, Pasparakis M, Kleinschmidt JA, Schwaninger M, Trepel M (2016) A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. EMBO Mol Med 8:609-625.

Loss GJ, Depner M, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Roduit C, Kabesch M, Lauener R, Pfefferle PI, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ (2016) The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21. Am J Respir Crit Care Med 193:889-897.

Rademacher L, Prinz S, Winz O, Henkel K, Dietrich CA, Schmaljohann J, Mohammadkhani Shali S, Schabram I, Stoppe C, Cumming P, Hilgers RD, Kumakura Y, Coburn M, Mottaghy FM, Grunder G, Vernaleken I (2016) Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers. Biol Psychiatry 80:198-206.

Storck SE, Meister S, Nahrath J, Meissner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU (2016) Endothelial LRP1 transports amyloid-beta(1-42) across the blood-brain barrier. J Clin Invest 126:123-136.

Warner A, Mittag J (2016) Breaking BAT: can browning create a better white? J Endocrinol 228:R19-29.

Winkler M, Schuchard J, Stölting I, Vogt FM, Barkhausen J, Thorns C, Bader M, Raasch W (2016) The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced obesity in rats. Br J Pharmacol 173:1602-1617.

Wostmann M, Herrmann B, Maess B, Obleser J (2016) Spatiotemporal dynamics of auditory attention synchronize with speech. Proc Natl Acad Sci U S A 113:3873-3878.

To top