Neurobiochemistry

Department of Neurology

Group Members

Andreas Moser (Group leader)
Sonya Neto (Postdoc)
Kevin Joseph (PhD student)
Marie-Luise von Byern Reher (Technician)
Karin Wiegers (Technician)


Research Interests

  • Modulation of the dopaminergic reward system by intranasal application of neuropeptides
  • Electrical high frequency stimulation of basal ganglia structures in the rat in vitro and in vivo
  • Mechanisms of deep brain stimulation
  • The role of GABA release through the GABA transporter as anti-seizure mechanism in human cerebral cortex
  • Microdialysis experiments in freely moving rats


Collaborations

  • Thomas J. Feuerstein, Neurocenter, University of Freiburg
  • Ulrich G. Hofmann, Department of Neurosurgery, University Hospital Freiburg
  • Joachim Scholz, Department of Anesthesiology, Columbia University, USA
  • Anett Schumacher, Department of Psychology, University of Toronto, Canada
  • Susanne Löffler, Department of Neuroscience, Karolinska Institutet Stockholm, Sweden 


Latest Publications

  1. Varatharajan R, Joseph K, Carvalho Neto S, Hofmann UG, Moser A, Tronnier V (2015). Electrical high frequency stimulation modulates GABAergic activity in the nucleus accumbens of freely moving rats. Neurochem Int, doi: 10.1016/j.neuint.2015.10.002. [Epub ahead of print]
  2. Tronnier VM, Domingo A, Moll CK, Rasche D, Mohr C, Rosales R, Capetian P, Jamora RD, Lee LV, Münchau A, Diesta CC, Tadic V, Klein C, Brüggemann N, Moser A (2015). Biochemical mechanisms of pallidal deep brain stimulation in F-linked dystonia parkinsonism. Parkinsonism Relat Disord 21, 954-959.
  3. Xie Y, Heida T, Stegenga J, Zhao Y, Moser A, Tronnier V, Feuerstein TJ, Hofmann UG (2014). High frequency electrical stimulation suppresses cholinergic accumbens interneurons in acute rat brain slices through GABAB receptors. Eur J Neuroscience 40, 3653-3662.
  4. Prauss K, Varatharajan R, Joseph K, Moser A (2014). Transmitter self-regulation by extracellular glutamate in fresh human cortical slices. J Neural Transm 121, 1321-1327.
  5. Richter A, Xie  Y, Schumacher A, Loeffler S, Kirch R, Al-Hasani J, Rapoport DH, Kruse C, Moser A, Tronnier V, Danner S, Hofmann  UG (2013). A simple implantation method for flexible, multisite microelectrodes into rat brains. Frontiers in Neuroengineering 6, 1- 6. doi: 10.3389/fneng.2013.00006