Chronophysiology

Institute of Neurobiology

Group Members

Henrik Oster (Group leader)
Christiane Koch (Postdoc)
Mariana Astiz (Postdoc)
Brinja Leinweber (PhD student)
Isabel Heyde (PhD student)
Isa Kolbe (PhD student)
Jana-Thabea Kiehn (PhD student)
Anne-Marie Neumann (PhD student)
Ada Tse (PhD student)
Maureen Friedrichs (MD student)
Christopher Blaum (MD student)
Britta Drengberg (MD student)
Nadine Oster (Lab manager)
Ludmilla Skrum (Technician)


Research Interests

We are interested in function and output of circadian clocks in mice and humans:

  • How is the clock synchronized to external time?
  • How is time information transmitted from the SCN to the periphery?
  • How does the clock coordinate physiological processes?

To address these questions we use behavioral, physiological, molecular biological and (mouse) genetic experimental approaches.


Collaborations

  • Gregor Eichele, MPI Göttingen, Germany
  • Christoph Scheiermann, LMU Munich, Germany
  • Kai-Florian Storch, McGill University Montreal, Canada
  • Moritz Rossner, LMU Munich, Germany


Latest Publications

  1. Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C. Immunity. 2017 Jan 17;46(1):120-132. doi: 10.1016/j.immuni.2016.12.011.PMID: 28087238
  2. The functional and clinical significance of the 24-h rhythm of circulating glucocorticoids. Oster H, Challet E, Ott V, Arvat E, de Kloet ER, Dijk DJ, Lightman S, Vgontzas A, Van Cauter E. Endocr Rev. 2016 Oct 17:er20151080. [Epub ahead of print]. PMID: 27749086
  3. Oxyntomodulin regulates resetting of the liver circadian clock by food.Landgraf D, Tsang AH, Leliavski A, Koch CE, Barclay JL, Drucker DJ, Oster H. Elife. 2015 Mar 30;4:e06253. doi: 10.7554/eLife.06253. PMID: 25821984
  4. Impaired glucocorticoid production and response to stress in Arntl-deficient male mice. Leliavski A, Shostak A, Husse J, Oster H. Endocrinology. 2014 Jan;155(1):133-42. doi: 10.1210/en.2013-1531. PMID: 24189141
  5. Circadian regulation of lipid mobilization in white adipose tissues. Shostak A, Meyer-Kovac J, Oster H. Diabetes. 2013 Jul;62(7):2195-203. doi: 10.2337/db12-1449. PMID: 23434933