Human Energy Homeostasis

Department of Internal Medicine I

Group Members

Sebastian Schmid (Group leader)
Britta Wilms (PostDoc)
Rodrigo Chamorro (PostDoc)
Alexander Iwen (PostDoc)
Hannes Kalscheuer (PostDoc)
Flavia Ihling (Medical doctor)
Filipa Gama (Medical doctor)
Georg Serfling (Medical doctor)
Jenny Backhaus (PhD student)
Anne Windjäger (Study nurse)
Susanne Behling (Technician)

Research Interests

As the prevalence of metabolic disorders such as obesity and type 2 Diabetes is constantly rising, our main research interest is on the regulation of human energy balance. All our research is done in a clinical experimental setting in healthy participants and patients within the Metabolic Core Unit (MCU) of the CBBM. A special focus of our work is on

  • homeostatic vs. hedonic control of hunger/appetite and food intake
  • regulation of glucose homoeostasis
  • physical activity, exercise and energy expenditure
  • neurocognitive impact of food
  • metabolic consequences of brown adipose tissue activity
  • chronobiological rhythms in the context of human energy balance

We use a broad spectrum of techniques comprising comprehensive hormone analysis, neurocognitive and behavioral testing, food analysis, gold-standard glucose clamp techniques, indirect calorimetry for the assessment of energy expenditure, air displacement plethysmography (BOD POD®) and dual energy X-ray absorptiometry (DEXA) for precise body composition measurement, and accelerometry and continuous heart rate monitoring for the assessment of physical activity under free-living conditions.

We finally seek to identify homeostatic, behavioral and endogenous mechanism impacting on humans´ metabolic health and energy expenditure. Our findings provide deeper insights into mechanisms promoting obesity and related metabolic disorders and may help to develop novel therapeutic strategies.


  • Sadaf Farooqi, University of Cambridge, UK
  • Jörg Heeren, UKE Hamburg, Germany
  • Manfred Hallschmid, University of Tübingen, Germany
  • Tinh-Hai Collet, University of Lausanne, Switzerland

Latest Publications

  1. Collet TH, van der Klaauw AA, Henning E, Keogh JM, Suddaby D, Dachi SV, Dunbar S, Kelway S, Dickson SL, Farooqi IS, Schmid SM (2016):The Sleep/Wake Cycle is Directly Modulated by Changes in Energy Balance. Sleep. 2016 Jun 9. pii: sp-00156-16.
  2. Schultes B, Panknin AK, Hallschmid M, Jauch-Chara K, Wilms B, de Courbière F, Lehnert H, Schmid SM (2016): Glycemic increase induced by intravenous glucose infusion fails to affect hunger, appetite, or satiety following breakfast in healthy men. Appetite. 2016 Jun 26. pii: S0195-6663(16)30260-4
  3. Schmid SM, Hallschmid M, Schultes B (2014): The metabolic burden of sleep loss. Lancet Diabetes Endocrinol. 2015 Jan;3(1):52-62
  4. Wilms B, Ernst B, Schmid SM, Thurnheer M, Schultes B (2013): Enhanced thermic effect of food after Roux-en Y gastric bypass surgery. J Clin Endocrinol Metab. 2013 Sep;98(9):3776-84
  5. Schmid SM, Hallschmid M, Jauch-Chara K, Wilms B, Benedict C, Lehnert H, Born J, Schultes B (2009): Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men. Am J Clin Nutr. 2009 Dec;90(6):1476-82.