Human Energy Homeostasis

Institute of Endocrinology and Diabetes

Group Members

Sebastian Schmid (Group leader)
Britta Wilms (PostDoc)
Svenja Meyhöfer (Medical Doctor)
Agnetha Schulz (Medical Doctor)
Eleni Pappa (Medical Doctor)
Georg Serfling (Medical Doctor)
Beatrice Bertozzi (PhD Student)
Shirin Tabei (PhD Student)
Franziska Richter (Phd Student)
Xueqi Cheng (PhD Student)
Jessika Schmidt (Project Coordination and Study Nurse)
Binja Tams (Secretary)
Meike Thamm (Study Nurse)
Susanne Behling (Technican)

Research Interests

Our main research interest is on the regulation of human energy balance with a special focus of glucose homoeostasis as well as metabolic consequences of brown adipose tissue activity. We also aim to understand underlying mechanisms of homeostatic versus hedonic control of hunger and satiety and consequently food intake. Further, chronobiological rhythms in the context of human energy balance play a major role in our research efforts.

We use a broad spectrum of techniques comprising gold-standard glucose clamp techniques, comprehensive hormone analyses, neurocognitive and behavioral testing, indirect calorimetry for the assessment of energy expenditure, air displacement plethysmography and MRI for precise body composition measurement, and accelerometry for the assessment of physical activity and sleep under free-living conditions.

We finally seek to identify homeostatic, behavioral and endogenous mechanism impacting on humans´ metabolic health and energy expenditure. As the prevalence of metabolic disorders such as obesity and related metabolic disorders is constantly rising, our findings provide deeper insights into mechanisms promoting obesity and may help to develop novel therapeutic strategies.

Collaborations

  • Sadaf Farooqi, University of Cambridge, UK
  • Jörg Heeren, UKE Hamburg, Germany
  • Manfred Hallschmid, University of Tübingen, Germany
  • Tinh-Hai Collet, University of Lausanne, Switzerland
  • Florian Kiefer, University of Vienna, Austria
  • Camilla Scheele, University of Copenhagen, Denmark

Latest Publications

  1. Koch CE, Begemann K, Kiehn JT, Griewahn L, Mauer J, M E Hess, Moser A, Schmid SM, Brüning JC, Oster H. Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA. Nat Commun. 2020;11(1):3071.
  2. Meyhöfer S, Wilms B, Ihling F, Windjäger A, Kalscheuer H, Augustinov A, Herrmann V, Lehnert H, Schmid SM. Evaluation of a near-infrared light ultrasound system as a non-invasive blood glucose monitoring device. Diabetes Obes Metab. 2020;22(4):694-698.
  3. Steinhardt J, Münte T, Schmid SM, Wilms B, Brüggemann N. A systematic review of body mass gain after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. Obes Rev. 2020;21(2):e12955
  4. Wilms B, Chamorro R, Hallschmid M, Trost D, Forck N, Schultes B, Mölle M, Sayk F, Lehnert H, Schmid SM (2019) Timing Modulates the Effect of Sleep Loss on Glucose Homeostasis. J Clin Endocrinol Metab. 2019;104(7):2801-2808.
  5. Wilms B, Leineweber EM, Mölle M, Chamorro R, Salinas-Riester G, Sina C, Lehnert H, Oster H, Schmid SM. Sleep loss disrupts morning-to-evening differences in human white adipose tissue transcriptome. J Clin Endocrinol Metab 2019;104(5):1687-1696.