1 DFG funded Position for PhD studies available (E13 - 65%)

in the group of Epigenetics and Metabolism (AG Prof Kirchner)

The group of Epigenetics and Metabolism (AG Prof Kirchner) is looking for a highly motivated PhD student in the framework of the DFG funded CRC-TR LocoTact. The position will be in the project ”Control of cellular TH metabolism in human and mouse NASH” and investigates the role of reduced thyroid hormone (TH) action for the development of nonalcoholic steatohepatitis (NASH) and whether reactivation of thyroid hormone signaling can be beneficial for disease reversal. The project will study the underlying mechanisms using human liver biopsies and iPSC derived hepatocytes specifically focusing on epigenetic mechanisms.

The position (TV-L, E13, 65%) is available from 01.03.2021 for at least 3 years. The applicant should have a Master’s degree in Biochemistry, Molecular Life Science or similar and should be able to communicate in English; a FELASA B certification would be beneficial. Experience in molecular and cell biology techniques and a thorough knowledge of physiology and genetics are advantageous. Techniques that will be applied throughout the projects include DNA, RNA and protein extraction, PCR, DNA methylation analysis by pyrosequencing, gene expression analysis, and cell culture. The student will be enrolled into the integrated CRC-TR graduate school (https://www.uni-due.de/crctr296/graduate-school) with a specific and exciting educational curriculum in addition to the laboratory work, including courses at our partner sites in Essen and Berlin.

More details on the group and our work can be found at https://www.cbbm.uni-luebeck.de/forschungszentrum/arbeitsgruppen/kirchner.html and www.cbbm.uni-luebeck.de/forschungszentrum/arbeitsgruppen/mittag.html.

Please follow the application procedure (https://www.uni-due.de/crctr296/graduate-school) by email including CV, masters certificate and application form in one single PDF to locotact(at)uk-essen.de with cc: to henriette.kirchner(at)uni-luebeck.de and jens.mittag(at)uni-luebeck.de as soon as possible.