Paper on oxytocin effects in autism accepted for publication in Biological Psychiatry: Global Open Science

People with autism spectrum disorders (ASD) have been found to be less sensitive to social rewards (e.g., smiles or praise), which is associated with diminished activation in the brain’s “reward circuit”. Oxytocin plays a major role in reward processing, and its administration by nasal spray might be a novel treatment option for ASD. In a randomized, double-blind, crossover study conducted at the CBBM, Mayer et al. showed that oxytocin did not substantially modulate reward-related brain activation in men with and without ASD, which suggests that its therapeutic use might be limited.

Mayer A V., Preckel K, Ihle K, Piecha FA, Junghanns K, Reiche S, et al. (2021): Assessment of reward-related brain function after a single-dose of oxytocin in autism: a randomized controlled trial.Biol Psychiatry Glob Open Sci https://doi.org/10.1016/j.bpsgos.2021.10.004