Diabetes: Study on the satiety mechanism brings new insights

An international research team with participation from the University of Lübeck has investigated the role of the brain in type 2 diabetes.

To better understand the disease, the researchers, led by the institute national de la santé et de la recherche médicale (Inserm), spent several years studying the role of leptin, a hormone involved in appetite control that sends satiety signals to the brain. In a new study published in the journal Nature Metabolism, the scientists have not only increased knowledge of the mechanism of satiety, but also developed a new mouse model for diabetes that will be useful and relevant for future research in this area.

Press release: www.uni-luebeck.de/aktuelles/pressemitteilung/artikel/diabetes-studie-zum-saettigungsmechanismus-bringt-neue-erkenntnisse.html 

Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function (2021)  Nature Metabolism 3, 1071–1090