Does Tanycytes in the brain promote well-aging?

Synergy Grant: Vincent Prévot, Markus Schwaninger und Ruben Nogueiras (from left to right)

European Research Council funds joint project in Lübeck, France and Spain with 9,9 Mio EUR

Together with Vincent Prévot from France (Inserm, Université de Lille, CHU de Lille) and Ruben Nogueiras from Spain (Universidade de Santiago de Compostela) Markus Schwaninger, Chair of the Institute for Experimental and Clinical Pharmacology and Toxicology at the University of Lübeck, will be funded by a renowned and highly endowed Synergy Grant of the European Research Council (ERC). The research team receives 9.9 Mio EUR within 6 years to investigate the role of special brain cells, the tanycytes, for well-aging. The Lübeck team will get 2.9 Mio EUR for this project.  

In an increasingly elderly European society, well-aging is a key challenge. Well-being across life requires a constant dialogue between the brain and the periphery. Indeed, to take informed and appropriate decisions and maintain the homeostasis of the body, the brain needs to be informed of what is happening in the periphery in real-time. The master regulator of these different homeostatic processes is the hypothalamus, a tiny structure hidden at the bottom of the brain. The WATCH research team, based at the universities of Lille, Lübeck and Santiago de Compostela, aims to demonstrate that tanycytes at the floor of the third ventricle in the median eminence of the hypothalamus act as linchpins of these processes.

The research team intends to employ state-of-the-art technologies in molecular systems neuroscience, mouse genetics and translational bench-to-bedside research, to explore the role of the uniquely versatile tanycytes in health and disease, and to generate new directions in biomarker research and new therapeutic approaches for a variety of disparate disorders that impair well-aging.