Individualized EEG/MEG targeted and optimized multi-channel transcranial electric stimulation: Neurophysiological evaluation and clinical application

by Prof. Dr. Carsten Wolters, Institute for Biomagnetism and Biosignalanalysis, University of Münster

will take place on Tuesday, May 28st, 2024 from 16:00 to 17:00 hours in CBBM Building, Ground Floor, Seminar Room Levi-Montalcini.

Host: Prof. Dr. med. Rebekka Lencer
Department of Psychiatry and Psychotherapy

Abstract: My talk will address targeted (by combined MEG/EEG source analysis) and optimized multi-channel transcranial direct current stimulation (mc-tDCS), from the methodology to the evaluation of its efficacy in neurophysiological group studies and first clinical applications. For mc-tDCS optimization I will present our recently developed algorithm - Distributed Constrained Maximum Intensity (D-CMI) - used on a target region which is determined by mean of combined MEG/EEG source analysis in realistic and skull-conductivity calibrated finite-element head models. For calibration, we will discuss complementarity and sensitivity of (OPM-)MEG and EEG. In a somatosensory group study, our individually targeted and optimized stimulation will be shown to be superior to standard bipolar tDCS. Finally, in a double blind sham-controlled study, the new methodology is applied in two pharmaco-resistant focal epilepsy patients, where the effect on interictal epileptiform discharges and seizure frequencies is investigated.