will take place on Tuesday, December 13, 2016 from 17:15 to 18:15 hours in CBBM Research Building, EG, Room 50/51.
Host: Prof. Hendrik Lehnert
Department of Internal Medicine I
Universität zu Lübeck
Abstract
The Tübingen family study collects people with increased risk to develop type 2 diabetes and comprises by now approx. 3.000 deeply phenotyped individuals. We used wholebody MRI imaging to assess bodyfat distribution patterns. We could identify subphenotypes of bodyfat distribution, a metabolically healthy phenotype of obesity (MHO) versus a metabolically unhealthy phenotype (MUHO) as well as distinct patterns of perivascular adiopose tissue as well as neckfat.
In a subgroup of approx. 250 individuals we studied brain insulin effects by MEG and fMRI and observed brain insulin resistance in obese people. We used nasal insulin as a tool to study brain effects in the fMRI.
Stimulation of brain insulin signalling by nasal insulin caused brain responses related to homeostatic regulation, eating behaviour but also caused changes of peripheral insulin sensitivity as determined by glucose clamp. Based on stable isotope techniques this brain derived signals affect both glucose appearance from the liver as well as glucose disappearance. Low hypothalamic insulin sensitivity correlated with increased visceral fat and decreased subcutaneous fat. We hypothesize that the brain insulin resistance causes unfavourable fat distribution patterns as a consequence of impaired signalling from the brain to the periphery favouring accumulation of visceral fat. This mechanism might also favour the develoment of NAFLD.
CV
PROFESSIONAL EXPERIENCE:
Present Position:
Head of the IVth Medical Department, University of Tübingen
Chair of Internal Medicine, Endocrinology, Diabetes, Angiology, Nephrology and Clinical Chemistry
1986-1996: Head of the Clinical Experimental Department, Institute for Diabetes Research and Oberarzt, IIIrd Medical Department of the Schwabing City Hospital
1983 - 1986: IIIrd Medical Department of the Schwabing City Hospital and Institute for Diabetes Research
1982-1983: Post doctoral fellowship at the Joslin Diabetes Research Laboratories, Harvard Medical School, Boston
1977-1981: Institute of Diabetes Research, Munich
AWARDS:
2016 Von Mering Medaille
2015 Claude Bernard Lecture
2014 Member of the National Academy of Science Leopoldina Germany
2011 Hellmut Mehnert Award , together with Prof. Dr. Errol Morrison
2010 Dr. h.c. of the University of Athens2010
2008 Paul Langerhans award of the German Diabetes Association
1989 Oskar Minkowski award, European Association for the Study of Diabetes
1986 Bertram price of the German Association for Diabetes research
PROFESSIONAL EDUCATION:
1992 Professor of Internal Medicine, Ludwig-Maximilians Universität, München
1986 "Habilitation" thesis, Ludwig-Maximilians Universität, München
1978 MD thesis, Ludwig-Maximilians Universität, München
MD degree obtained in 1976, Ludwig-Maximilians Universität, München
PUBLICATION RECORD
Hirsch (h) Factor: 81
POSITIONS IN SCIENTIFIC ADVISORY BOARDS
Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke, 2002 - 2010 (Leibniz-Institut)
Robert-Bosch Foundation, 2002 – 2010
School of Clinical Medicine, University of Cambridge, Addenbrookes Hospital, since 2008
Deutsches Diabetes Zentrum, Düsseldorf, SAB since 1998-2015, chair since 2002-2013 (Leibniz-Institut)
Co-chair of the Deutsches Zentrum für Diabetesforschung (Helmholtz-Institut)
Member of the Scientific Committee of the International Symposia on Insulin Receptor and Insulin Action” since 1990
ACADEMIC POSITIONS
Study dean of the University of Tübingen, 2002 - 2006
