Researcher Team from the CBBM identifies novel role of thyroid hormone in early brain development

New Publication within the Transregio TRR296 LocoTact

Thyroid hormones regulate a plethora of metabolic pathways and are important for brain development. A lack of the hormone after birth due to congenital hypothyroidism can cause severe developmental delays in brain development. This occurs in around 1 in 3600 newborns. Now the research groups of Prof. Dr. Malte Spielmann and Prof. Dr. Jens Mittag from the Center of Brain, Behavior and Metabolism (CBBM) at the University of Lübeck have identified the cell types that are most heavily affected. The results have been published in the prestigious journal “Development”.

The published work was performed in the framework of the DFG funded TRR296 “LocoTact” to decipher the local actions of thyroid hormones, which in addition to the University of Lübeck also includes the Universitätsklinikum Essen and the Charité Berlin.

Original publication: Sreenivasan VKA, Dore R, Resch J, Maier J, Dietrich C, Henck J, Balachandran S, Mittag J*, Spielmann M*. Singlecell RNAbased phenotyping reveals a pivotal role of thyroid hormone receptor alpha for hypothalamic development. Development 2023;150.