Cytoskeletal mechanisms in motor axon remodelling

by PD Dr. Monika Leischner-Brill, Institute of Neuronal Cell Biology, Technical University of Munich

will take place on Tuesday, July 18th, 2023 from 16:00 to 17:00 hours in CBBM Building, Ground Floor, Seminar Room Levi-Montalcini.

Host: Prof. Julian Grosskreutz
Department of Neurology, University of Lübeck

Abstract: PD Dr. rer nat. Monika Leischner-Brill is a leading researcher in axonal physiology and pathology. She did her doctoral thesis at the department of physiological genomics at the LMU Munich with Magdalena Götz on regionalization of adult neurogenesis and discovered a new interneuron cell type generated at the subventricular zone (Brill et al., Journal of Neuroscience 2008; Brill et al, Nature Neuroscience 2009). She continued her research at the institute of neuronal cell biology of the Technical University Munich with Thomas Misgeld. Here she focussed on axonal transport and cytoskeletal remodelling using high level light microscopy and live imaging techniques to dissect the mechanisms of developmental synapse elimination (Brill et al., JCB 2011; Brill et al., Neuron 2016). Having achieved status of independent researcher with her own group in 2022, her more recent work analyses mechanisms of axonal remodelling in ageing (Metzner, … , Brill. Frontiers Cell Dev Biol, 2022) and disease, in particular in motor neurone diseases, collaborating with i.e. Julian Grosskreutz, head of Precision Neurology in Neuromuscular and Motoneuron Diseases at the University of Lübeck.