ONLINE CBBM Lecture - Advanced tools to study peripheral and central synapses

by Alberto Perez Alvarez, PharmD, PhD, University Medical Center Hamburg-Eppendorf

Center for Molecular Neurobiology Hamburg (ZMNH) , Institute of Synaptic Physiology

will take place on Tuesday, December 1, 2020 from 17:15 to 18:15 hours.


Host: Markus Schwaninger
Institute for Experimental and Clinical Pharmacology and Toxicology
University of Lübeck

At synapses, a chemical signal is converted into fast electrical deflections leading to a plethora of downstream effects including self-regulation (i.e. plasticity). Since this process of synaptic transmission is altered in several neurological disorders, it is therefore an attractive but complex target for pharmacological intervention. I will describe here state-of-the-art optogenetics, electrophysiological and imaging technology that helps monitor and control at high resolution the transfer of information across synapses in nervous circuits. In combination with OMIC approaches, they hold the promise of improving our understanding of nerve pathophysiology and develop tailored therapy.